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Kinase activity is contained within BRD4 subregions spanning BD2-B-BID domains. A, schematic map of WT, deletion mutants, and fragments of BRD4. B, in vitro kinase assay using radiolabeled ATP showing autophosphorylation of WT, tΔC, and ΔN recombinant BRD4 proteins, all at 50 nM. Kinase activity relative to WT is shown. C, in vitro kinase assays of 200 nM BRD4 275 to 730 aa fragment using radiolabeled ATP and 100 nM GST-CTD27-52 and 100 nM GST-TAF7 as substrates.
