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. 2021 Oct 25;24(11):103337. doi: 10.1016/j.isci.2021.103337

Figure 1.

Figure 1

Clearance of LPS by LSEC is via a receptor-mediated mechanism; however, TLR4 is not involved in the rapid clearance of LPS by LSEC

(A) Plot for 488-LPS bound to LSEC in a dose-dependent manner versus concentration of 488-LPS along with excess of unlabeled LPS, HDL, and LBP incubated at 37°C for 1 h.

(B) The curve plots the remainder of 3H/14C double-labeled LPS in blood circulation versus time in WT C57BL/6 and TLR4-KO mice at various time points after intravenous (IV) infusion. Each data point represents the mean and SD of data from three mice/biological replicates. The figures represent two different experiments.