Table 1.
Immune profiling gene panel in LSEC treated with LPS
| Gene | Fold change | p value | Gene | Fold change | p value |
|---|---|---|---|---|---|
| Ptgs2 | 45.23 | 6.8E-05 | Tap1 | 2.15 | 3.6E-06 |
| Ccl3 | 10.98 | 7.5E-10 | Irf7 | 2.13 | 2.6E-05 |
| Cd69 | 9.71 | 3.3E-03 | Stat1 | 2.09 | 1.0E-05 |
| Il1b | 9.02 | 8.4E-08 | Traf1 | 1.96 | 1.9E-03 |
| Ccl5 | 7.58 | 5.0E-09 | Cd40 | 1.90 | 3.6E-05 |
| Cxcl10 | 7.02 | 2.3E-10 | Cd83 | 1.90 | 1.1E-05 |
| Ifit2 | 4.92 | 2.4E-08 | Pml | 1.84 | 1.6E-05 |
| Cxcl11 | 4.71 | 2.7E-08 | Cd86 | 1.81 | 2.3E-05 |
| Il15 | 4.36 | 8.9E-06 | Tlr2 | 1.78 | 1.9E-03 |
| Il1a | 4.35 | 1.0E-07 | Ifi35 | 1.74 | 3.6E-05 |
| Ccl4 | 3.98 | 1.2E-07 | Stat2 | 1.72 | 1.9E-03 |
| Il6 | 3.89 | 4.7E-06 | Csf1 | 1.65 | 1.7E-06 |
| Ifih1 | 3.63 | 2.2E-08 | Tnfaip3 | 1.64 | 1.8E-06 |
| Cd274 | 3.58 | 4.0E-07 | Bst2 | 1.64 | 5.5E-06 |
| Ifnb1 | 3.46 | 9.8E-06 | Ccl9 | 1.63 | 5.7E-04 |
| Tnf | 3.41 | 2.0E-05 | Cdkn1a | 1.61 | 8.0E-04 |
| Ccrl2 | 2.97 | 1.4E-07 | Sele | 1.59 | 2.4E-05 |
| Slamf7 | 2.97 | 1.0E-05 | Icam1 | 1.58 | 5.8E-04 |
| Il1rn | 2.81 | 3.5E-08 | Cfb | 1.57 | 4.8E-04 |
| Irgm1 | 2.79 | 1.2E-08 | Mapkapk2 | 1.55 | 3.0E-04 |
| Ccl7 | 2.65 | 2.4E-07 | Tapbp | 1.54 | 3.3E-04 |
| Cybb | 2.59 | 5.6E-07 | Ptpn2 | 1.52 | 5.7E-03 |
| Cxcl3 | 2.58 | 2.6E-04 | Plaur | 1.51 | 2.3E-05 |
| Ifi204 | 2.52 | 2.9E-07 | C1qb | 0.66 | 3.0E-04 |
| Ddx58 | 2.51 | 2.2E-07 | Cfp | 0.64 | 7.3E-04 |
| Cxcl1 | 2.39 | 4.8E-07 | C1qa | 0.59 | 1.7E-04 |
| Socs1 | 2.39 | 2.2E-04 | Tyrobp | 0.59 | 2.4E-04 |
| Clec4e | 2.34 | 5.7E-06 | Ctss | 0.57 | 1.9E-05 |
| Irf1 | 2.32 | 1.9E-06 | Ccl24 | 0.54 | 3.0E-04 |
| Ccl2 | 2.30 | 8.8E-08 | Fcgr1 | 0.49 | 1.1E-04 |
| Tumor nec | 2.21 | 8.1E-05 | Marco | 0.49 | 7.2E-04 |
| Tnfsf15 | 2.19 | 2.1E-03 | Tlr8 | 0.48 | 5.4E-04 |
| Vcam1 | 2.15 | 4.5E-06 | Aicda | 0.34 | 2.2E-03 |
Total RNA purified from LPS-treated or untreated LSEC was used for NanoString analysis by using nCounter Mouse Pan Cancer Immune Profiling Panel. The relative expression of each transcript was normalized against the expression of the top genes with counts >100. Each value is the mean of biological triplicates, and the ratios between means per target genes provide linear fold change. Two-tailed Student's t-test is used to select differentially expressed genes with values <0.005.