Comparison 7. Early (immediate) cyclophosphamide + steroids versus late (when SCr increase > 25%) cyclophosphamide + steroids.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
7.1 Death	1	26	Risk Ratio (M‐H, Random, 95% CI)	0.29 [0.01, 6.50]
7.2 ESKD (dialysis/transplantation)	1	26	Risk Ratio (M‐H, Random, 95% CI)	2.60 [0.12, 58.48]
7.3 Complete or partial remission	1	26	Risk Ratio (M‐H, Random, 95% CI)	1.14 [0.77, 1.69]
7.4 Complete remission	1	26	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.39, 1.45]
7.5 Partial remission	1	26	Risk Ratio (M‐H, Random, 95% CI)	4.29 [0.58, 31.79]
7.6 Temporary or permanent discontinuation/hospitalisation due to adverse events	1	26	Risk Ratio (M‐H, Random, 95% CI)	0.29 [0.07, 1.16]
7.7 Final serum creatinine	1	26	Mean Difference (IV, Random, 95% CI)	‐12.00 [‐73.26, 49.26]
7.8 Final GFR [mL/min/1.73 m²]	1	26	Mean Difference (IV, Random, 95% CI)	8.00 [‐8.59, 24.59]
7.9 Final proteinuria	1	26	Mean Difference (IV, Random, 95% CI)	0.59 [‐0.64, 1.82]