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. 2021 Nov 15;2021(11):CD004293. doi: 10.1002/14651858.CD004293.pub4

Comparison 10. Calcineurin inhibitors ± steroids versus placebo/no treatment/supportive treatment/steroids.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
10.1 Death 7   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
10.1.1 Death (any cause) 7 296 Risk Ratio (M‐H, Random, 95% CI) 1.69 [0.46, 6.14]
10.1.2 Death due to deteriorating kidney function 3 111 Risk Ratio (M‐H, Random, 95% CI) 2.27 [0.35, 14.75]
10.2 ESKD (dialysis/transplantation) 7 296 Risk Ratio (M‐H, Random, 95% CI) 1.18 [0.54, 2.60]
10.3 Complete or partial remission 5 206 Risk Ratio (M‐H, Random, 95% CI) 1.21 [0.62, 2.38]
10.3.1 Complete or partial remission (< 2 years) 3 92 Risk Ratio (M‐H, Random, 95% CI) 0.99 [0.30, 3.22]
10.3.2 Complete or partial remission (≥ 2 years) 2 114 Risk Ratio (M‐H, Random, 95% CI) 1.69 [0.39, 7.28]
10.4 Complete remission 5 206 Risk Ratio (M‐H, Random, 95% CI) 1.07 [0.51, 2.24]
10.4.1 Patients with normal kidney function 4 185 Risk Ratio (M‐H, Random, 95% CI) 1.22 [0.51, 2.92]
10.4.2 Patients with deteriorating kidney function 1 21 Risk Ratio (M‐H, Random, 95% CI) 0.36 [0.02, 8.03]
10.5 Partial remission 5 206 Risk Ratio (M‐H, Random, 95% CI) 1.08 [0.53, 2.22]
10.5.1 Patients with normal kidney function 4 185 Risk Ratio (M‐H, Random, 95% CI) 1.19 [0.51, 2.78]
10.5.2 Patients with deteriorating kidney function 1 21 Risk Ratio (M‐H, Random, 95% CI) 0.73 [0.15, 3.53]
10.6 Relapse after complete or partial remission 2 92 Risk Ratio (M‐H, Random, 95% CI) 1.56 [0.79, 3.09]
10.7 Increase in serum creatinine 3   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
10.7.1 100% increase in serum creatinine 2 117 Risk Ratio (M‐H, Random, 95% CI) 0.84 [0.37, 1.86]
10.7.2 50% increase in serum creatinine 2 99 Risk Ratio (M‐H, Random, 95% CI) 0.55 [0.05, 5.75]
10.8 Temporary or permanent discontinuation/hospitalisation due to adverse events 5 161 Risk Ratio (M‐H, Random, 95% CI) 5.45 [0.29, 101.55]
10.9 Adverse events 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
10.9.1 Serious adverse events 1 75 Risk Ratio (M‐H, Random, 95% CI) 1.16 [0.70, 1.90]
10.9.2 Infection 1 73 Risk Ratio (M‐H, Random, 95% CI) 4.11 [0.94, 18.06]
10.9.3 Malignancy 1 107 Risk Ratio (M‐H, Random, 95% CI) 2.79 [0.14, 56.57]