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. Author manuscript; available in PMC: 2021 Nov 20.
Published in final edited form as: Nat Rev Dis Primers. 2021 May 20;7(1):36. doi: 10.1038/s41572-021-00267-0

Fig. 3 |. Timeline of milestones in the understanding and treatment of PKU.

Fig. 3 |

The initial description and major advances in the understanding of hyperphenylalaninaemia (HPA) and phenylketonuria (PKU) pathogenesis are shown. Furthermore, developments in the treatment of PKU are also highlighted. BH4, tetrahydrobiopterin; HPLC, high-performance liquid chromatography; PAH, phenylalanine hydroxylase.