Table 11. In Vivo Pharmacokinetics of 23 in Rat and Dog.

species	rata		dogb
route of administration	i.v.	p.o.	i.v.	p.o.
clearance (mL/min/kg)	4.5		13.7
Vd (L/kg)	0.6		1.3
T1/2 (h)	2.8		1.5
F (%)		94		39

^an = 3 male SD rats, 2 mg/kg i.v., 10 mg/kg p.o.

^bn = 2 male Beagle dogs, 1 mg/kg i.v., 5 mg/kg p.o.