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. 2021 Oct 29;64(21):16159–16176. doi: 10.1021/acs.jmedchem.1c01437

Table 2. Collated EC50 Values for Compounds 1, 3 and the Current Front-Line Antileishmanial Miltefosine.

  EC50 values, μMa
compound intramacrophage L. donovani intramacrophage L. infantum PMM
1 59 >64 >64
3 1.2 2.7 >64
23 1.4 1.8 >64
miltefosine 10 10 33
a

Geometric mean value of at least three independent assays. PMM: primary mouse macrophages.