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. 2021 Oct 29;64(21):16159–16176. doi: 10.1021/acs.jmedchem.1c01437

Table 3. In Vivo Efficacy of Compound 3 in an L. infantum Hamster Model of VL, after QD Dosing for 5 Daysa.

  reduction in parasite burden, %
dose (mg/kg) liver spleen bone marrow
25 87.8 81.8 81.6
50 97.4 95.0 91.2
100 98.6 96.0 88.3
a

n = 6 animals per group, results were expressed as a percentage reduction in amastigote burden compared to vehicle-treated, infected control animals.