Table 3. In Vivo Efficacy of Compound 3 in an L. infantum Hamster Model of VL, after QD Dosing for 5 Daysa.
| reduction
in parasite burden, % |
|||
|---|---|---|---|
| dose (mg/kg) | liver | spleen | bone marrow |
| 25 | 87.8 | 81.8 | 81.6 |
| 50 | 97.4 | 95.0 | 91.2 |
| 100 | 98.6 | 96.0 | 88.3 |
n = 6 animals per group, results were expressed as a percentage reduction in amastigote burden compared to vehicle-treated, infected control animals.