Table 6. Antileishmanial Activity of Selected Compounds against L. donovani.
| MRC5a |
|||||
|---|---|---|---|---|---|
| compound | intramacrophage L. infantum EC50 (μM)a | intramacrophage L. donovani EC50 (μM)a | PMMa CC50 (μM) | CC50 (μM) | SIb |
| 5 | 1.6 | 1.0 | 53.8 | >64 | >64 |
| 16 | 3.1 | 1.2 | >64 | 61.1 | 52 |
| 23 | 1.8 | 1.4 | >64 | >64 | >46 |
| 28 | 0.5 | 0.4 | 54 | 18 | 45 |
| 31 | 2.0 | 9.4 | >64 | >64 | >7 |
a
Geometric mean value of at least two independent tests.
b
Selectivity index representing the ratio of CC50/EC50; data are presented as the geometric mean value of ratios calculated using separate data from at least two independent tests.