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| reduction
in liver parasite burden following 5 days of p.o. dosing BIDa, % |
|||
|---|---|---|---|
| compound | dose (mg/kg), BID | L. infantum | L. donovani |
| 23 | 25 | 96.1 | 97.1 |
| 50 | 98.6 | 99.7 | |
| 28 | 25 | n.d. | 97.5 |
| 50 | n.d. | 99.5 | |
n = 5 animals per group, the results were expressed as a percentage reduction in parasite burden compared to vehicle-treated, infected control animals, n.d., not determined.
