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. 2021 Oct 27;12(11):1629–1632. doi: 10.1021/acsmedchemlett.1c00543

Figure 1.

Figure 1

Schematic for the mode of action of molecular glue and PROTAC. These protein degraders bring the protein of interest into close proximity to the ubiquitination system, allowing for polyubiquitination and proteasome dependent degradation.