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. 2021 Oct 5;12(11):1802–1809. doi: 10.1021/acsmedchemlett.1c00416

Figure 2.

Figure 2

(A) Effects of pregabalin (1) and 16RR on mechanical hypersensitivity (allodynia) induced by intraplantar injection of capsaicin (1 μg) to mouse hind paw. The results represent the percentage reduction in capsaicin-induced mechanical hypersensitivity. (B) Effect of 1 and 16RR on motor coordination using the rotarod test. The results represent the latencies to fall-down from the elevated rotating drum. Rotarod latencies were measured at 30, 120, and 180 min after administration of vehicle or compounds 1 and 16RR at 20 mg/kg ip.