Table 2. Broad-Spectrum Anti-influenza Activity of Compounds 12c, 12e, 13c, and 13d.
A/Hong
Kong/4801/2014 (H3N2) |
B/Sichuan/531/2018
(Victoria) |
||||
---|---|---|---|---|---|
compound | CC50 (μM) | IC50 (μM) | SI | IC50 (μM) | SI |
12c | >100 | 1.71 ± 0.44 | >58.48 | 37.63 ± 2.03 | >2.66 |
12e | >100 | 1.20 ± 0.27 | >83.33 | >100 | – |
13c | >100 | 2.67 ± 0.26 | >37.45 | 28.35 ± 1.61 | >3.53 |
13d | >100 | 4.58 ± 0.13 | >21.83 | 1.87 ± 0.23 | >53.48 |
OSV-p | >100 | >100 | – | >100 | – |