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. 2021 Oct 25;12(11):1847–1852. doi: 10.1021/acsmedchemlett.1c00483

Figure 3.

Figure 3

Joint compression threshold (mean ± SEM) over time for qd and BID administration of 1 in a rat MIA model (N = 10 rats/treatment). Animals were injected with MIA on day −14, and treatment with either vehicle or 1 began on day 0 continuing through day 15. Baseline (BL) recordings occurred immediately prior to the AM dose administration. JCTs measured on day 16 occurred 24 h after the last administration of vehicle or 1. Significance of effects of 1 treatment (qd or BID administration) compared to vehicle-treated animals was calculated at each time point using a two-way repeated-measures ANOVA followed by Tukey’s multiple comparisons (*P < 0.05; **P < 0.01).