Table 3. Pharmacokinetic Data for Compound 3a.
| species | dose (mpk) iv/po | CLiv (mL/min/kg) | F% | oral AUC (nM·h) |
|---|---|---|---|---|
| mouse | 2/10 | 85 | 100% | 5406 |
| rat | 2/10 | 50 | 94% | 6500 |
| dog | 1/1 | 17 | 61% | 1230 |
| monkey | 1/1 | 16 | 63% | 1300 |
Values are means obtained from three or more animals.
| species | dose (mpk) iv/po | CLiv (mL/min/kg) | F% | oral AUC (nM·h) |
|---|---|---|---|---|
| mouse | 2/10 | 85 | 100% | 5406 |
| rat | 2/10 | 50 | 94% | 6500 |
| dog | 1/1 | 17 | 61% | 1230 |
| monkey | 1/1 | 16 | 63% | 1300 |
Values are means obtained from three or more animals.