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. 2021 Oct 15;12(11):1753–1758. doi: 10.1021/acsmedchemlett.1c00373

Table 3. Pharmacokinetic Data for Compound 3a.

graphic file with name ml1c00373_0006.jpg

species dose (mpk) iv/po CLiv (mL/min/kg) F% oral AUC (nM·h)
mouse 2/10 85 100% 5406
rat 2/10 50 94% 6500
dog 1/1 17 61% 1230
monkey 1/1 16 63% 1300
a

Values are means obtained from three or more animals.