Table 2. Comparison of the Bioactivity of Diastereomeric Mixture 14 and BNM-III-170 against Various HIV-1 Viral Strainsa.
| viral strain | amino acid 105 identity | IC50 (μM) 14b | IC50 (μM) BNM-III-170b |
|---|---|---|---|
| JR-FL | GIn | 8.29 ± 5.66 | 9.00 ± 5.14 |
| A4 | His | 98.9 ± 63.0c | 200 ± 42.7 |
| 191084 | His | 20.6 ± 3.10c | 95.9 ± 52.9 |
| BG505 | His | 130 ± 28.3c | 226 ± 47.4 |
a
All IC50 values are reported as the mean ± standard deviation.
b
The IC50 was determined in Cf2Th-CD4/CCR5 cells infected with the HIV-1 virus of the strains indicated.
c
Improvement in viral inhibiton compared to BNM- III-170 found to be statistically significant in a one-tailed unpaired t test (P < 0.05, N = 3).