Table 4. Summary of Compound 15.

In Vitro
CDK8 IC50 (nM)	1
CDK19 IC50 (nM)	2
Clinta (μL·min–1·mg–1)	15

In Vivo Mouse PKb
CMaxc (μM)	1.04
AUClast (min × ng/mL)c	51863
T1/2c (h)	1.3
Cl (mL·min–1·kg–1)	17
Vss (L/kg)	0.8
F (%)	8

^aMouse hepatocytes.

^bFormulation: 0.2 mg/mL (IV) and 1 mg/mL (PO) solution in 5/95 DMSO/30% Captisol; 2 mg/kg IV dose and 10 mg/kg PO dose.

^cFollowing PO dose.