Table 2. Inhibitory Effects of the Tested Compounds 11 and 13 after Incubation for 72 h with MNT-1 (Human Melanoma), B16F10 (Murine Melanoma), HaCaT (Human Keratinocyte), and A375 (Human Melanoma) Cells.
| IC50 (μM) |
||||
|---|---|---|---|---|
| compound | MNT-1 | B16F10 | A375 | HaCaT |
| 11a | >75 | >75 | nda | >150 |
| 11b | 74.1 ± 2.9 | 78.3 ± 2.7 | nd | >130 |
| 11c | >75 | >75 | nd | >150 |
| 11d | 49.4 ± 1.6 | 51.0 ± 1.5 | 43.8 ± 3.3 | >100 |
| 11e | >75 | >75 | nd | >150 |
| 13a | >75 | >75 | 55.0 ± 3 | nd |
| 13b | Nd | >75 | 47.0 ± 1.6 | 45.8 ± 1.2 |
| 13c | >75 | >75 | >75 | nd |
| 13d | >75 | >75 | 61.0 ± 4 | nd |
| 13e | >75 | >75 | >75 | nd |
| 13f | nd | >75 | >75 | >75 |
| 4a | >60 | >60 | nd | >60 |
| 4c | >60 | >60 | nd | >60 |
| 4d | >60 | >60 | nd | >60 |
| 4e | >75 | >75 | nd | >130 |
| 10 + 4e | 37.1 ± 1.9 | >75 | nd | 130 ± 8.7 |
| 10 | 42.8 ± 1.4 | >75 | nd | >125 |
| TMZ | >75 | >75 | >75 | >75 |
a
nd: not determined.