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. 2021 Nov 2;12(11):1794–1801. doi: 10.1021/acsmedchemlett.1c00412

Table 2. PI3K Isoform Ki and PIM Isoform IC50 Dataa.

Nr PI3Kα PI3Kβ PI3Kδ PI3Kγ PIM-1 PIM-2 PIM-3
28 0.25 0.37 0.08 0.44 18.2 13.3 4.39
31 0.27 0.31 0.13 0.17 22.8 8.04 5.75
a

The values are the average of two independent experiments in nM. Ki for PI3K isoforms was determined with a HTRF technology assay. IC50 for PIM-1 was determined via ADP Hunter Plus assay.