Table 3. Pharmacokinetic Profile of MCXs 28 and 31^a.

route	parameter	28	31
I.V.	dose	1	0.7
	AUClast	16 596	11 176
	T1/2	3.66	2.96
	Cl	0.060	0.063
	Vd	0.31	0.26
P.O.	dose	10	5
	Cmax	2929	9370
	Tmax	0.25	5
	T1/2	23.4	14.6
	AUClast	58 235	99 055
	F%	35.08	124

^aPK studies. The data were adjusted to a noncompartmental model using Winnolin software. Units: Dose (mg/kg); area under the curve AUC (h.ng/mL); half-life T_1/2 (h); clearance Cl (L/h/kg); volume of distribution V_d (L/kg); maximun concentration C_max (ng/mL); time of maximum concentration T_max (h).