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The hypothesis of neuroplasticity involving BDNF in the pathogenesis of depression. Chronic stress leads to a decrease in hippocampal BDNF expression, causing a reduction in the binding of BDNF to TrkB receptors needed for activation of the BDNF-TrkB signaling pathway (indicated by solid arrows). This results in compromised neuroplasticity, and reduced neuronal survival rate, dendritic growth, spine density, synaptogenesis, and maturation of neurons
