Table 1.
Lipid Profiles for Distinguishing Between Squamous Cell Carcinoma Tumor Tissues and Adjacent Noninvolved Tissues.
| Lipid | Retention time | m/z | Mode | P values | FC | FDRp value | AUC | PLS-DA-VIP |
|---|---|---|---|---|---|---|---|---|
| ADGGA(56:7) | 13.05 | 939.620 | NEG | 1.81E-07 | 1.05 | 8.38E-05 | 0.89 | 1.678 |
| DAG(36:5) | 10.01 | 632.525 | POS | 6.73E-09 | 1.06 | 3.13E-05 | 0.86 | 1.719 |
| HBMP(52:2) | 13.09 | 871.613 | NEG | 8.71E-09 | 1.04 | 3.13E-05 | 0.9 | 1.546 |
| HexCer-AP(t8:0/29:1 + O) | 11.47 | 818.599 | NEG | 1.74E-06 | 0.94 | 2.29E-04 | 0.88 | 1.65 |
| HexCer-AP(t8:0/32:2 + O) | 13.14 | 858.631 | NEG | 3.93E-07 | 0.95 | 1.04E-04 | 0.87 | 1.707 |
| HexCer-NDS(d24:0/18:5) | 10.99 | 802.62 | NEG | 2.68E-07 | 1.05 | 9.47E-05 | 0.86 | 1.544 |
| PA(50:4) | 12.87 | 883.623 | NEG | 2.6E-08 | 0.98 | 4.72E-05 | 0.85 | 1.502 |
| PC(44:4) | 16.13 | 894.693 | POS | 1.64E-06 | 0.94 | 2.29E-04 | 0.89 | 1.536 |
| PC(40:4) | 12.15 | 882.624 | NEG | 3.27E-08 | 0.96 | 4.72E-05 | 0.88 | 1.522 |
| PE(18:0e/28:7) | 13.16 | 858.638 | NEG | 5.71E-07 | 0.95 | 1.28E-04 | 0.86 | 1.643 |
| PE-Cer(t24:0/26:7) | 15.67 | 887.664 | NEG | 1.64E-06 | 0.93 | 2.29E-04 | 0.86 | 1.569 |
| PI(46:7) | 13.39 | 991.636 | NEG | 9.79E-07 | 1.04 | 1.81E-04 | 0.88 | 1.578 |
| SM(d18:1/20:0) | 13.03 | 803.633 | NEG | 5.73E-08 | 1.03 | 4.72E-05 | 0.86 | 1.702 |
| TAG(46:7) | 13.04 | 782.625 | POS | 4.59E-08 | 1.03 | 4.72E-05 | 0.85 | 1.668 |
Abbreviations: AUC, area under the receiver operating characteristic curve; FC, fold change of date after log10-transformed; FDRp, false discovery rate calculated from Wilcoxon test; m/z, mass-to-charge ratio; PLS-DA-VIP, variable importance in projection values of partial least squares-discriminant analysis.