Table 4.
Risk of sequential acquisition of genital HPV following an oral HPV infection of the same type
| 9vHPVa N=320 |
High-Risk HPVb N=342 |
Low-Risk HPVc N=391 |
||
|---|---|---|---|---|
| Crude Model | ||||
| Prior Oral Infection d | Yes | 3.4 (2.1–5.5) | 3.5 (2.0–6.1) | 9.3 (3.6–23.9) |
| Adjusted Model | ||||
| Prior Oral Infection e | Yes | 3.5 (1.9–6.4) | 3.2 (1.6–6.4) | 16.4 (4.2–65.1) |
| P prior oral | <0.001 | 0.001 | <0.001 | |
| Age | 18–30 | |||
| 31–44 | 0.7 (0.4–1.3) | 0.7 (0.4–1.3) | 0.4 (0.2–0.99) | |
| 45–73 | 0.8 (0.4–1.7) | 0.7 (0.4–1.5) | 0.5 (0.2–1.5) | |
| P age | 0.496 | 0.478 | 0.115 | |
| Country | US | |||
| Brazil | 1.5 (0.8–2.7) | 1.5 (0.8–2.9) | 2.4 (0.9–6.8) | |
| Mexico | 0.5 (0.2–1.2) | 0.5 (0.2–1.2) | 0.7 (0.2–2.6) | |
| P country | 0.043 | 0.031 | 0.059 | |
| Circumcision | Yes | |||
| No | 1.3 (0.8–2.3) | 1.3 (0.70–2.3) | 1.4 (0.6–3.5) | |
| P circumcision | 0.331 | 0.436 | 0.467 | |
| Number of Alcoholic Drinks Consumed in the Past Month | 0 | |||
| 1–30 | 1.1 (0.6–2.1) | 1.01 (0.5–2.2) | 1.4 (0.4–4.5) | |
| 31–60 | 1.9 (0.8–4.2) | 2.0 (0.9–4.5) | 2.3 (0.6–8.1) | |
| >60 | 1.7 (0.8–3.5) | 1.3 (0.6–3.04) | 1.6 (0.5–5.5) | |
| Refused | 1.3 (0.3–6.4) | 1.5 (0.3–7.9) | 4.5 (0.4–51.0) | |
| P alcohol | 0.436 | 0.384 | 0.662 | |
| Lifetime Number of Sex Partners | 0–2 | |||
| 3–7 | ||||
| 8–19 | 2.1 (0.9–4.5) | 2.5 (1.2–5.4) | 1.9 (0.6–6.6) | |
| >19 | 2.7 (1.2–5.8) | 2.7 (1.2–6.2) | 3.9 (1.2–12.2) | |
| Refused | 3.9 (1.5–10.2) | 3.4 (1.1–10.5) | 2.6 (0.6–12.3) | |
| P sex partners | 0.038 | 0.060 | 0.121 | |
| Number of Times Gave Oral Sex in the past Six Months | 0 | |||
| 1–6 | 0.8 (0.4–1.6) | 1.02 (0.5–2.02) | 1.1 (0.4–3.01) | |
| 7–24 | 1.4 (0.7–2.7) | 1.4 (0.7–3.0) | 1.4 (0.5–3.9) | |
| >25 | 1.2 (0.6–2.6) | 1.1 (0.5–2.4) | 1.4 (0.4–4.6) | |
| Refused | 1.2 (0.4–3.6) | 1.5 (0.5–4.8) | 0.9 (0.1–6.8) | |
| P oral sex | 0.612 | 0.852 | 0.952 | |
Abbreviations: HR: Hazard ratio; aHR: adjusted Hazard Ratio; CI: Confidence Interval
Bolded values indicate significance with p<0.05
Infections due to any of the 9 vaccine-type HPVs: 6, 11, 16, 18, 31, 33, 45, 52, 58
Infections due to HPV 16, 18, 31, 33, 45, 52, 58
Infections due to HPV 6 and 11
Cox proportional Hazard Model: univariate analysis for risk of HPV infection by prior oral HPV infection status
Cox proportional Hazard Model adjusted for prior oral HPV infection status, age, country, circumcision, number of alcoholic drinks consumed in the past month, lifetime number of sex partners, and number of times oral sex was given in the past six months.