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. 2021 Nov 2;12(11):1745–1752. doi: 10.1021/acsmedchemlett.1c00371

Table 1. Kd Values of Compounds 5a–5c, 6a–6c, 8, and 9 (μM)a.

  galectins (N = N-terminal domain, C = C-terminal domain)
compd 1 2 3 4N 4C 7 8N 8C 9N 9C
2(21) 420 NAb 4100 >1000 >3000 NAb 180 NAb >1000 >1000
3 1600 ± 140 NAb 3300 ± 650 2400 ± 13 5300 NAb 1300 ± 72 4100 ± 470 NBc 4800
methyl β-d-galactoside19,31,32 >10 000 13000 4400 6600 1000 NAb 6300 >30 000 3300 8600 ± 7309
5a 2200 ± 138 NAb 1300 ± 130 1700 ± 60 2600 ± 230 NAb 400 ± 34 3000 ± 380 NBc NAb
5b 840 ± 20 NAb 680 ± 37 NAb NAb NAb 690 ± 53 1500 ± 180 NAb NAb
5c NBc NAb 1200 ± 287 3200 2500 NAb 180 ± 19 3000 ± 300 NBc NBc
6a 1300 ± 130 1400 ± 24 690 ± 30 1400 ± 30 1700 ± 150 NBc 48 ± 4 4000 ± 500 1400 ± 57 NBc
6b 1100 ± 87 NAb 770 ± 129 3600 2500 ± 300 NAb 810 ± 54 3000 ± 30 NBc NBc
6c NBc 990 ± 170 550 ± 32 1400 ± 230 1900 ± 400 NBc 46 ± 4 NAb NBc 2500
8 NBc NBc 1700 ± 40 1300 ± 12 3700 ± 250 NAb 230 ± 16 NBc 1000 ± 51 NBc
9 3600 1100 ± 200 590 ± 78 NBc 2800 ± 770 NBc 48 ± 6 4700 ± 22 1800 ± 160 NBc
a

Results represent the mean ± SEM of n = 4–8.

b

Not available.

c

Nonbinding up to the highest tested concentration of 1500 μM.

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