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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2020 Nov 27;109(5):1483–1494. doi: 10.1016/j.ijrobp.2020.11.052

Figure 4. In vivo tumor penetration of Cis-Pt released from implants.

Figure 4.

Figure 4.

Figure 4.

(A) Assessment of Pt distribution in different sections of the tumors after treatment with empty or Cis-Pt implants using two different methods: ICP-MS and immunofluorescence (IF). (B) Pt concentration in each tumor layer from Cis-Pt implant group (n=3) by ICP-MS analysis, adjusted with background signal from empty implant group (n=3). (C) Fluorescence microscopy images of regions of tumor sections, stained with antibody for Cis-Pt induced DNA adducts (AF488) and counterstained with DAPI. Gray lines indicate the edge of the tissue.