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. 2021 Nov 12;9:e12434. doi: 10.7717/peerj.12434

Figure 5. Mapping the surface locations of some of the identified CSIs in the spike protein by homology modeling.

Figure 5

(A) Homology models of the spike protein from BatSARS-like-CoVZC45 based on the available structures of SARS-CoV-2 (PDB IDs: 6vsb, and 6m17) and SARS-CoV-2 spike proteins (PDB ID: 6vsb). (B) A cartoon and surface representation of a Cryo-EM structure of the SARS CoV spike protein (PDB ID: 6acc). (C) A cartoon and surface representation of a spike protein from SARS-CoV-2. The S1-NTD and S1-CTD domains are homology models based on the experimental structure of the SARS-CoV-2 spike protein (PDB ID: 6vsb, and 6m17). In all of these models, the S1-NTD and S1-CTD domains are shown in cyan and dull green color, respectively, whereas the S2 subunit is shown in bright green color. The identified CSIs in the S1-NTD and S2-CTD domains of these CoVs are labeled and shown in blue and red colors, respectively. The asterisk (*) in (B) indicates that the CSI ⑦is only found in SARS-viruses but not present in bat-RShSTT-CoVs.