TABLE 1.

Anatomical differences in skin structures between different animal models and humans

Criteria	Rodents	Guinea Pig	Pig	Human
Skin attachment	Loose	Loosely attached	Firmly attached	Firmly attached
Hair coat	Dense (breed exceptions, ie, nude mice)	Sparse or dense	Sparse	Sparse
Epidermis	Thin	Thick	Thick	Thick
Dermis	Thin	Thick	Thick	Thick
Panniculus carnosus	Present	Present	Absent	Absent
Eccrine glands	Absent except in paw pads	Absent	Absent	Present
Dominant mechanism of closure	Contraction	Contraction	Re-epithelialization	Re-epithelialization