Comparison 2. SSRI versus control at end of follow up, by SSRI.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Disability (studies at low risk of bias only)	2	2591	Mean Difference (IV, Fixed, 95% CI)	‐0.24 [‐2.59, 2.11]
2.2 Independent on modified rankin score (0‐2) (studies at low risk of bias only)	2	3137	Odds Ratio (M‐H, Fixed, 95% CI)	1.03 [0.89, 1.19]
2.3 Depression, continuous data (studies at low risk of bias only)	2	2684	Mean Difference (IV, Fixed, 95% CI)	0.04 [‐0.36, 0.44]
2.4 Depression, dichotomous (studies at low risk of bias only)	1	3083	Odds Ratio (M‐H, Fixed, 95% CI)	0.87 [0.73, 1.04]
2.5 Motor deficits (studies at low risk of bias only)	2	2688	Mean Difference (IV, Fixed, 95% CI)	‐0.77 [‐3.00, 1.46]
2.6 Cognition (studies at low risk of bias only)	2	2689	Mean Difference (IV, Fixed, 95% CI)	‐0.35 [‐2.32, 1.62]
2.7 Death (studies at low risk of bias only)	2	3144	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.77, 1.12]
2.8 Leaving the trial before the end of follow‐up, for reasons other than death ( studies at low risk of bias)	2	3188	Odds Ratio (M‐H, Fixed, 95% CI)	0.90 [0.54, 1.51]
2.9 Disability, all studies irrespective of risk of bias	2	2691	Mean Difference (IV, Fixed, 95% CI)	‐0.25 [‐2.56, 2.06]
2.10 Independent on mRS (0‐2) all studies irrespective of risk of bias	2	3134	Odds Ratio (M‐H, Fixed, 95% CI)	1.03 [0.89, 1.19]