| Study characteristics |
| Methods |
To investigate the effect of early antidepressant intervention on the acute depression and rehabilitation of neurological function after stroke |
| Participants |
96 acute depression patients after stroke were selected and randomly divided into study group and control group. Stroke diagnosed according to the diagnostic criteria of stroke by the 4th Congress of Chinese Cerebrovascular Diseases, which requires both clinical and imaging criteria to be met. HAMD ≥ 17. Excluded patients with mental disorders. Range of disease: 2‐9 months |
| Interventions |
The study group orally took the antidepressant ( citalopram) and the control group took placebo for 8 weeks |
| Outcomes |
Depression (HAMD), neurological function (NIHSS), ADL (BI). Substance P and neuropeptide Y |
| Funding source |
No information regarding funding |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Random number table |
| Allocation concealment (selection bias) |
Unclear risk |
Information not provided |
| Blinding of participants and personnel (performance bias)
All outcomes |
Unclear risk |
Information not provided |
| Blinding of outcome assessment (detection bias)
All outcomes |
Unclear risk |
information not provided |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
information not provided |
| Selective reporting (reporting bias) |
Unclear risk |
Information not provided |
| Other bias |
Unclear risk |
No information provided e.g. on source of funding |
