Huang 2002.

Study characteristics
Methods	Parallel design Aim: efficacy and tolerance of fluoxetine in early post‐stroke depression Analysis: according to treatment group
Participants	Country: China Setting: inpatient Stroke criteria: first ever stroke, with single unilateral lesion, clinical diagnosis with imaging consistent with stroke, both ischaemic and haemorrhagic, recruited 2 weeks after stroke onset Depression criteria: CCMD II‐R depression diagnosis Treatment: 40 people, age and gender not stated Control: 40 people, age and gender not stated Participants in the treatment and control groups were selected from a group of 168 first‐ever acute stroke patients with average age of 62 ± 8.1 years, 76 men
Interventions	Treatment: fluoxetine 20 mg daily Control: placebo Duration of treatment: 4 weeks Duration of follow‐up (treatment end to study end): 0
Outcomes	HAMD CSS Did not report death Unclear how AEs were reported: no obvious AEs were found, but they did not specifically report seizures
Funding source	Source of funding not stated
Notes	−
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method not stated
Allocation concealment (selection bias)	Unclear risk	Method not stated
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Placebo used, but unclear if identical
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	No dropouts, analysed according to treatment group
Selective reporting (reporting bias)	Unclear risk	No protocol
Other bias	Unclear risk	No description of the differences between treatment and control group in baseline characteristics