Li 2004a.

Study characteristics
Methods	Parallel group Aim: to study effects of fluoxetine on neurological impairment and post‐stroke depression
Participants	Location: China Setting: inpatient Stroke: inclusion: all pathological types, clinical diagnosis plus confirmation by imaging that relevant lesion visible, CSS 16 to 30 Depression criteria: HAMD scores ≥ 17 and DSM IV diagnostic criteria Treatment: 33 people, mean age 60.33 years, 24 men Control: 34 people, mean age 60.44 years, 23 men Excluded severe psychiatric disorders, severe cardiac, pulmonary, hepatic and renal disease
Interventions	Treatment: fluoxetine 20 mg daily plus routine acute stroke care Control: routine acute stroke care Duration of treatment: 4 weeks Duration of follow‐up (end of treatment to end of study): 0
Outcomes	CSS Depression incidence Laboratory monitoring parameters AEs (method of reporting not stated)
Funding source	Source of funding not stated
Notes	−
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer random numbers
Allocation concealment (selection bias)	Low risk	Opaque sealed envelopes
Blinding of participants and personnel (performance bias) All outcomes	High risk	No placebo
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	No dropouts
Selective reporting (reporting bias)	Unclear risk	No protocol
Other bias	Low risk	Balanced baseline