Li 2004b.

Study characteristics
Methods	Parallel design Aim: to treat depression
Participants	Country: China Setting: inpatient Stroke criteria: ischaemic stroke, clinical diagnosis plus imaging confirmation (though not clear that a relevant lesion had to be seen), stroke onset time ≤ 7 days Depression criteria: HAMD score ≥ 8 Treatment: 37 people, age 48 to 87 years, 17 men Control: 36 people, age 53 to 82 years, 15 men Exclusion: previous depression or psychiatric interview, dementia (according to MMSE scores), aphasia, severe cardiac, pulmonary, hepatic, renal function impairment, consciousness disturbance
Interventions	Treatment: fluoxetine 20 mg daily plus usual stroke care Control: usual stroke care Duration: 8 weeks Duration of follow‐up (treatment end to study end): 0
Outcomes	HAMD CSS (cannot use as reported as a categorical variable) MMSE (reported as a dichotomous variable) BI (reported as a dichotomous variable) Data for continuous variables not provided Death reported Side effects in treatment group only reported, not control group. Method of reporting side effects not stated
Funding source	Source of funding not stated
Notes	Note that the sum of numbers in each category of HAMD at 8 weeks in the control group adds up to 30, not 32
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method not described
Allocation concealment (selection bias)	Unclear risk	Method not described
Blinding of participants and personnel (performance bias) All outcomes	High risk	No placebo
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not stated
Incomplete outcome data (attrition bias) All outcomes	High risk	Dropouts: 6 in treatment and 4 in control group. Total dropouts = 10/73 (14%)
Selective reporting (reporting bias)	Unclear risk	No protocol
Other bias	Unclear risk	Baseline balanced