Li 2006.

Study characteristics
Methods	Parallel group
Participants	All pathological types of stroke, CT or MRI needed for diagnosis Inclusion criteria: depression diagnosed by Chinese Classification of Mental Disorders 3 and HAMD ≥ 18, no previous organic brain disorder, and no previous psychiatric history, clear consciousness, no comprehension problems, normal language, first acute stroke, first episode of depression Treatment: 52 people, mean ± SD age 61.12 ± 10.25, 32 men Control: 53 people, mean ± SD age 60.89 ± 9.12, 35 men
Interventions	Treatment: citalopram 20 mg daily plus usual care Control: usual care Duration of treatment: 12 weeks Duration of follow‐up (end of treatment to end of study): 0
Outcomes	HDRS (also known as HAMD) BI CSS MMSE Side effects reported according to the participant's complaints and observation, no description of who recorded AEs; and reported only for the treatment group
Funding source	Source of funding not stated
Notes	−
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No description
Allocation concealment (selection bias)	Unclear risk	No description
Blinding of participants and personnel (performance bias) All outcomes	High risk	No placebo
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No description
Incomplete outcome data (attrition bias) All outcomes	High risk	2 dropouts in treatment group, 4 in control group. 1 in treatment group died, and 2 in the control group died (i.e. > 5%)
Selective reporting (reporting bias)	Unclear risk	No protocol
Other bias	Low risk	Baseline balanced