Skip to main content
. 2021 Nov 15;2021(11):CD009286. doi: 10.1002/14651858.CD009286.pub4

Miao 2004.

Study characteristics
Methods Parallel group
9 not allocated (5 in treatment group refused allocation, 4 in the control group refused allocation)
Participants Country: China
Setting: mixed inpatient and outpatient
All stroke pathological types, clinical diagnosis plus confirmation by imaging that a relevant lesion was visible, 2 to 8 months after stroke, clear consciousness, no comprehension problem, 1 lesion in 1 hemisphere, normal language comprehension
Mood: depression after stroke onset, HAMD score ≥ 20
Participants: 90 randomised, 34 in each group at treatment end
Treatment: 34 people, age 58.16 ± 8.49 years, 19 men
Control: 34 people, age 62.45 ± 8.24 years, 18 men
Exclusion criteria: other organic brain disorders and other aetiologies‐related depression
Interventions Treatment: citalopram 20 mg daily plus usual stroke care
Control: usual stroke care
Duration of treatment: 6 weeks
Duration of follow‐up (treatment end to study end): 0
Outcomes HAMD
SDS
Efficacy
Death
AEs (only in the citalopram group)
Method of recording AEs was not stated
Funding source Source of funding not stated
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "Simple random sampling"
Comment: no further description given
Allocation concealment (selection bias) Unclear risk Allocation not described
Blinding of participants and personnel (performance bias)
All outcomes High risk No placebo
Blinding of outcome assessment (detection bias)
All outcomes Low risk Blinding described
Incomplete outcome data (attrition bias)
All outcomes High risk 9 not allocated after randomisation, 13 dropouts
Selective reporting (reporting bias) Unclear risk No protocol
Other bias Unclear risk Baseline balanced