Pariente 2001.

Study characteristics
Methods	Prospective double‐blind cross‐over placebo‐controlled study of 8 people with pure motor hemiparesis
Participants	Lacunar ischaemic stroke, assessed by brain CT Quote: "Early phase of recovery"
Interventions	Single dose of fluoxetine
Outcomes	fMRI (raw data provided) Finger tapping (presented as a graph, no raw data) NIHSS, motricity index, BI, trunk control test, Ashworth Scale, somatosensory scale (no data)
Funding source	Source of funding not stated
Notes	We could not use these data in our meta‐analyses. The authors reported that fluoxetine led to hyperactivation in the ipsi‐lesional (i.e. on the same side as the stroke lesion) primary motor cortex during a motor task; moreover, fluoxetine significantly improved motor skills of the affected side Dates of recruitment not given. Conflicts not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomisation code kept at the centre and broken at the end of the study
Allocation concealment (selection bias)	Low risk	Randomisation code kept at the centre and broken at the end of the study
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind, placebo given
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Double‐blind
Incomplete outcome data (attrition bias) All outcomes	Low risk	Data on fMRI appears complete
Selective reporting (reporting bias)	Unclear risk	Data on clinical outcomes were not reported
Other bias	Low risk	Balanced baseline