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. 2021 Nov 15;2021(11):CD009286. doi: 10.1002/14651858.CD009286.pub4

Yang 2002.

Study characteristics
Methods Parallel group
Aim: to study effects of antidepressant in treatment of people with post‐stroke depression
Participants Country: China
Setting: inpatients and outpatients
Stroke criteria: recovery phase of stroke (2 to 6 months after ischaemic stroke, and 1.5 to 6 months after haemorrhagic stroke). We included this in the 3 to 6 month group. Clinical diagnosis of stroke (not stated whether confirmation by imaging was needed)
Depression: HAMD > 7
Treatment: 64 people, mean age 64 ± 3 years, 40 men
Control: 57 people, mean age 63 ± 5 years, 32 men
Interventions Treatment: paroxetine 20 mg daily plus stroke treatment and rehabilitation
Control: stroke treatment and rehabilitation
Duration of treatment: 4 months
Duration of follow‐up: 0
Outcomes Death
They collected data on HAMD and CSS but did not report these data
ADL score: did not state which one, so not used
AEs not reported
Funding source Source of funding not reported
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method not described
Allocation concealment (selection bias) Unclear risk Not described
Blinding of participants and personnel (performance bias)
All outcomes High risk No placebo
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Not described
Incomplete outcome data (attrition bias)
All outcomes High risk 11/121 (9%) dropouts
Selective reporting (reporting bias) High risk No protocol. The paper stated that ADL data and depression data were collected, but these data were not reported
Other bias Low risk No baseline differences between groups, no other obvious source of bias