Yang 2002.
Study characteristics | ||
Methods | Parallel group Aim: to study effects of antidepressant in treatment of people with post‐stroke depression |
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Participants | Country: China Setting: inpatients and outpatients Stroke criteria: recovery phase of stroke (2 to 6 months after ischaemic stroke, and 1.5 to 6 months after haemorrhagic stroke). We included this in the 3 to 6 month group. Clinical diagnosis of stroke (not stated whether confirmation by imaging was needed) Depression: HAMD > 7 Treatment: 64 people, mean age 64 ± 3 years, 40 men Control: 57 people, mean age 63 ± 5 years, 32 men |
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Interventions | Treatment: paroxetine 20 mg daily plus stroke treatment and rehabilitation Control: stroke treatment and rehabilitation Duration of treatment: 4 months Duration of follow‐up: 0 |
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Outcomes | Death They collected data on HAMD and CSS but did not report these data ADL score: did not state which one, so not used AEs not reported |
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Funding source | Source of funding not reported | |
Notes | − | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Method not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | High risk | No placebo |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not described |
Incomplete outcome data (attrition bias) All outcomes | High risk | 11/121 (9%) dropouts |
Selective reporting (reporting bias) | High risk | No protocol. The paper stated that ADL data and depression data were collected, but these data were not reported |
Other bias | Low risk | No baseline differences between groups, no other obvious source of bias |