NCT00967408.

Methods	Study type: interventional (clinical trial) Estimated enrolment: 200 participants Allocation: randomised Intervention model: parallel assignment Masking: quadruple (participant, care provider, investigator, outcomes assessor) Primary purpose: treatment
Participants	Country: Italy Setting: inpatient Inclusion criteria > 18 years First ischaemic or haemorrhagic stroke Exclusion criteria Unstable medical conditions Unable to understand study aims and procedures Severe aphasia Other progressive neurological disease Previous or concomitant psychiatric illness Not willing to participate
Interventions	Experimental: escitalopram and rehabilitation. Escitalopram given 5 mg once a day for the first week, 10 mg once a day from the second to fourth week, and 20 mg daily until the 6th month Comparator: placebo and rehabilitation
Outcomes	Primary outcome collected at 2 and 6 months FIM Secondary outcomes collected at 2 and 6 months: MMSE Trunk Control Test Canadian Stroke Scale Motricity Index Token test The Bells Test Stroop Test Wisconsin Card Sorting test Verbal Fluency Raven's Matrices Test Trail Making A‐B Test Center for Epidemiological Studies Depression Scale
Notes	clinicaltrials.gov/ct2/show/NCT00967408 Contacted author Prof Cisari; response received; data being analysed

BDI: Beck Depression Inventory
BI: Bathel Index
FIM: Functional Independence Measure
HAM‐D17: Hamilton Depression Scale
ICD‐10: International Statistical Classification of Diseases, 10th revision
IQR: interquartile range
MMSE: Mini‐Mental State Examination
NIHSS: National Institutes of Health Stroke Scale