ChiCTR1800019467.

Study name	The effect and mechanism of fluoxetine on the automatic regulation of cerebral blood flow for ischemic stroke
Methods	Study type: interventional (clinical trial) Estimated enrolment: Allocation: randomised Intervention model: parallel assignment Masking: unclear Primary purpose: treatment
Participants	China Inclusion criteria Age 30 to 80 years First‐time acute (in the past 72 hours) ischaemic stroke Diagnosis of stroke confirmed by imaging Consent Exclusion criteria Haemorrhagic stroke Coma Massive cerebral infarction Poor coordination of transcranial doppler ultrasonography Currently participating or have participated in other clinical trials within 3 months
Interventions	Experimental: 20 mg of fluoxetine daily for 90 days Comparator: conventional therapy
Outcomes	Baseline, 30 days after treatment, 90 days after treatment, 180 days after treatment Automatic regulation of cerebral blood flow
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