NCT02386475.

Study name	Effect of serotonin and levodopa in ischemic stroke (SELEIS)
Methods	Study type: interventional (clinical trial) Estimated enrolment: 240 participants Allocation: randomised Intervention model: parallel assignment Masking: single (outcomes assessor) Primary purpose: treatment
Participants	Country: Spain Setting: inpatient Inclusion criteria: Age > 18 years NIHSS 5 to 20 points mRS < 3 prior to stroke Participants without prior cognitive impairment or depressive syndrome Assigned treatment initiated within the first 5 days of stroke Exclusion criteria: Aphasia Prior myocardial or cerebral haemorrhage TIA History of cognitive impairment or prior depressive syndrome mRS 3 or higher Life‐threatening illness that is likely to reduce 1‐year survival Use of levodopa, an antidepressant or neuroleptic Aiming to recruit 240 participants.
Interventions	Placebo comparator: placebo Active comparator: citalopram 20 mg Active comparator: sinemet plus 100 mg Sinemet plus + citalopram group
Outcomes	Rankin Scale at 12 months
Starting date	1 January 2015. Study completed 31 October 2019. No results available‐contacted author on 4 May 2021
Contact information	Dolores Cocho mailto:dcocho%40fhag.es?subject=NCT02386475, SELEIS, Effect of Serotonin and Levodopa in Ischemic Stroke
Notes	NCT02386475