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. Author manuscript; available in PMC: 2021 Nov 15.
Published in final edited form as: Annu Rev Biophys. 2021 May 6;50:549–574. doi: 10.1146/annurev-biophys-111020-101511

Figure 2.

Figure 2

Model for plus-end recruitment of dynein-1. (a) Dynactin is recruited to the plus end by tip tracking proteins EB1 and CLIP-170. Lis1 binds to the dynein-1 motor domain and stabilizes the open conformation of dynein-1 in the cytoplasm. (b) Together with a cargo adaptor protein, dynactin recruits Lis1-bound dynein-1 in the open conformation to form the active complex. Following complex assembly, Lis1 dissociates from dynein as DDX moves processively toward the minus end of the MT. Abbreviations: DDX, dynein-1-dynactin-cargo adaptor; MT, microtubule.