Table 3.

Interventions considered

Intervention	Assumed Magnitude
Reduced Prescribing for Acute Pain	10% reduction in incidence of prescribing opioids for acute pain
Reduced Prescribing for Transitioning Pain	10% reduction in incidence of prescribing opioids for acute pain that transitions to chronic
Reduced Prescribing for Chronic Pain	10% reduction in incidence of prescribing opioids for chronic pain
Drug Rescheduling	10% reduction in chance of getting prescription renewed
Prescription Monitoring Program (PMP)	15% reduction in incidence of prescribing opioids for acute pain
	5% reduction in incidence of prescribing opioids for transitioning pain
	5% reduction in incidence of prescribing opioids for chronic pain
Drug Reformulation	2.25% reduction in iatrogenic use disorder
	2.25% reduction in chance of use disorder via diversion for pain-free non-users
	2.25% reduction in pill-seeking for individuals with SOUD without Rx
Excess Opioid Disposal - Policy 1	10% reduction in diversion to pain-free non-users
	10% reduction in number of individuals with SOUD without Rx able to be sustained by non-SOUD Rx holders
Excess Opioid Disposal - Policy 2	15% reduction in diversion to pain-free non-users
	15% reduction in number of individuals with SOUD without Rx able to be sustained by non-SOUD Rx holders
Naloxone Availability - Policy 1	5% reduction in overdose mortality
Naloxone Availability - Policy 2	15% reduction in overdose mortality
Naloxone Availability - Policy 3	30% reduction in overdose mortality
Pharmacotherapy	25% increased likelihood of entering pharmacotherapy
Psychosocial Treatment	10% increased likelihood of desistance
Syringe Exchange	10% reduction in infection mortality

Abbreviations: Rx = prescription; SOUD = severe opioid use disorder