Fig. 5.

Loss of cortical GluN2B alters dS firing after correct choices. (A) Electrode placement in dS for GluN2B^NULL and GluN2B^FLOX controls. (B) Baseline firing rate of dS neurons did not differ across genotypes. (C) dS neuronal firing increased following a correct choice in both genotypes. Firing decreased from discrimination to early reversal before slowly recovering back to discrimination levels. GluN2B^NULL had increased firing immediately prior to a correct choice on reversal session 3 and reduced firing during reward approach during chance reversal. (D) GluN2B^NULL and control mice had no change in firing following an error during discrimination. Both genotypes showed significant increases in firing following an error choice during reversal sessions 1, 3 and 4 with no effect of genotype. During chance reversal both groups also showed significant increases in firing following an error, however GluN2B^NULL mice had significantly reduced firing versus controls. Data are means ± SEM. N = 8 mice per genotype/recording session. Yellow band indicates reward cue (tone) and gray band error cue (house light). * = p < .01 main effect of time # = p < .01 main effect of genotype ‡ = p < .01 genotype × time interaction.