Fig. 8.

OFC-dS phase functional connectivity is significantly increased in GluN2B^NULL mice. (A) Inter-site phase consistency (ISPC) was seen in low levels in the low delta- theta range (1–5 Hz) for GluN2B^NULL mice during discrimination. (B) ISPC increased in both GluN2B^FLOX and GluN2B^NULL during the first session of reversal compared to discrimination, with higher levels in GluN2B^NULL compared to controls. (C) ISPC continued into reversal session 3, with differences in peak frequency of connectivity, GluN2B^NULL being within the low theta range ∼4 Hz and GluN2B^FLOX in delta range ∼1.5 Hz. (D) During the final reversal session, before chance performance was reached, ISPC was robust in both genotypes, and significantly increased in GluN2B^NULL mice, specifically in the theta range of ∼4 Hz. (E) When chance was re-attained during reversal, OFC-dS ISPC returned to discrimination levels in GluN2B^NULL mice, but remained elevated in GluN2B^FLOX mice. (F) Average ISPC within the TF-ROI plotted against session. There was a significant main effect of gentoype with GluN2B^NULL showing elevated ISPC, but no significant differences in ITPC by session between GluN2B^NULL mice and controls. Reversal S4 had significantly greater ISPC compared to all other sessions in controls. # p < 0.05 in controls, compared to all other sessions.