Fig. 9.

Granger prediction of OFC to dS functional connectivity is significantly increased in GluN2B^NULL mice. (A) Low levels of OFC to dS information transfer during choice decision in GluN2B^FLOX mice, and additionally before reward retrieval in GluN2B^NULL mice. (B) The majority of OFC to dS connectivity was shifted prior to correct choice during the first session of reversal in GluN2B^FLOX mice, and this response was blunted in GluN2B^NULL mice, but not significantly. (C) GluN2B^FLOX mice maintain OFC to dS connectivity pre-choice during reversal S3, which again is decreased but not significantly in GluN2B^NULL mice. (D) GluN2B^FLOX connectivity remains elevated during reversal chance pre-choice on reversal S4, while GluN2B^NULL mice remain to have decreased connectivity. (E) Once chance criterion is re-attained Granger prediction in GluN2B^FLOX mice returns to during choice decision at levels similar to those during initial discrimination. However, GluN2B^NULL mice have significantly elevated OFC to dS connectivity on reversal chance. (F) Average Granger prediction vales within the Choice and Tone TF-ROIs across sessions. Dotted lines (———) demarcate choice and offset of associative tone. Black rectangles represent significant effect of genotype. * p < 0.05 between genotypes.