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. Author manuscript; available in PMC: 2021 Nov 15.
Published in final edited form as: Anesth Analg. 2019 Aug;129(2):434–441. doi: 10.1213/ANE.0000000000004201

Table 1.

Toxicities from CAR T cell therapy

Constitutional Fevers
Malaise
Arthralgias
Myalgias
CNS Headache
Encephalopathy
Aphasia (expressive and receptive)
Tremors
Myoclonus
Paresis
Seizures
Cerebral edema
Cerebral Herniation
Cardiovascular Tachycardia
Arrhythmias
Heart block
Cardiomyopathy
Troponemia
Hypotension
Refractory vasoplegia/shock
Pulmonary Hypoxia
Tachypnea
Bronchospasm
Pulmonary edema
Pleural effusions
ARDS
Renal/Electrolytes Hyponatremia
Hypo/Hyperkalemia
Hypophosphatemia
Hypomagnesemia
AKI/ATN
Oliguria
Renal Failure requiring CRRT
GI Nausea/vomiting
Enterocolitis
Cholangitis
Hyperbilirubinemia
Transaminitis
GI hemorrhage
Hematologic Neutropenia
Anemia
Thrombocytopenia
Hyperferritinemia
Hypofibrinogenemia
DIC
HLH/MAS
Other Anaphylaxis
Tumor Lysis Syndrome
Infection