. Author manuscript; available in PMC: 2021 Nov 15.

Published in final edited form as: Anesth Analg. 2019 Aug;129(2):434–441. doi: 10.1213/ANE.0000000000004201

Tabel 2.

Consensus grading of CRS and Neurotoxicity

Toxicity	Features	Grade 1	Grade 2	Grade 3	Grade 4
CRS
	Fever	Present	Present	Present	Present
	Hypoxia		requiring low FiO2	requiring high FiO2	requiring positive pressure ventilation
	Hypotension		Fluid responsive	requiring one vasopressor	requiring multiple vasopressors
Neurotoxicity
	SCAN SCORE^*	SCAN 7–9	SCAN 3–6	SCAN 0–2	Unable to perform
	Level of Consciousness	normal	Mild lethargy	Severely lethargic	Obtunded/comatose
	Weakness				Deep focal motor weakness
	Seizures			Any seizure (focal or generalized) resolving with intervention	Life-threatening prolonged seizures with no return to baseline
	Cerebral Edema			Focal edema or hemorrhage on neuroimaging	Decorticate/decerebrate posturing Cushing’s triad Diffuse cerebral edema on neuroimaging

Orientation to year, month, city, hospital: 4 points; Name 3 objects: 3 points; Following complex commands: 1 point; Ability to write a standard sentence: 1 point; Attention: Count backwards from 10: 1 point⁵²