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. 2021 Nov 15;16(11):e0259966. doi: 10.1371/journal.pone.0259966

Fig 5. TgLRAP mice resisted bone loss induced by ovariectomy (OVX).

Fig 5

A, Fine focused radiographic analysis of femur. OVX WT showed decreased trabecular bone structures compared to other groups. B, 3D μCT evaluations of bone parameters. The left panel indicates the region of interest (ROI; yellow cylinder) for following measurements. The right panel indicates the tomography at the level of ROI. C and D, Parameters analyzed by μCT. BMD and BV/TV were decreased in OVX WT compared to other groups. BMD; bone mineral density. BV/TV; ratio of trabecular bone volume per total bone volume, each column represents the mean ± SD. n = 4 for each group. E, Quantitation of calcein incorporation into the calvaria. AU; arbitrary unit. Each column represents the mean ± SD. n = 4 for each group. F, Histological quantitation of bone resorption in sham-operated (Sham) /OVX WT or TgLRAP mice. The number of osteoclasts per bone perimeter (N.Oc/B.Pm (per 100 mm)) were compared. Each column represents the mean ± SD. n = 4 for each group. *p<0.05. WT; wild-type mouse, TgLRAP; LRAP transgenic mouse.