Table 3. Results of association analysis of three functional variants of SLC2A1 and SLC23A2 with cognitive decline (MCI or dementia).
| Gene symbol | SNP ID | Reference | Effect | Odds ratio | 95% CI | p value |
|---|---|---|---|---|---|---|
| Dominant model | ||||||
| SLC2A1 | rs710218 | TT | AA+TA | 1.51 | 0.95–2.38 | 0.081 |
| rs841851 | AA | GG+AG | 1.09 | 0.68–1.76 | 0.72 | |
| SLC23A2 | rs1279683 | GG | AA+GA | 0.93 | 0.58–1.51 | 0.77 |
| Log-additive model | ||||||
| SLC2A1 | rs710218 | T | A | 1.15 | 0.82–1.62 | 0.43 |
| rs841851 | A | G | 1.02 | 0.68–1.51 | 0.94 | |
| SLC23A2 | rs1279683 | G | A | 1.13 | 0.82–1.58 | 0.45 |
Odds ratio of the functional variant was calculated by multivariate logistic regression analysis, adjusted for the effects of APOE4 phenotype, baseline age, follow-up period, baseline MMSE points, and sex. The upper half shows the results of the dominant model and the lower half shows the results of the log-additive model.